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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIRT2
All Species:
0.61
Human Site:
S351
Identified Species:
1.11
UniProt:
Q8IXJ6
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IXJ6
NP_036369.2
389
43182
S351
L
V
R
R
E
H
A
S
I
D
A
Q
S
G
A
Chimpanzee
Pan troglodytes
XP_001168156
319
35635
I282
V
R
R
E
H
A
S
I
D
A
Q
S
G
A
G
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_855382
347
38546
A310
K
E
H
A
H
I
D
A
Q
A
G
S
G
A
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8VDQ8
389
43238
N351
L
V
R
R
E
H
A
N
I
D
A
Q
S
G
S
Rat
Rattus norvegicus
Q5RJQ4
350
39301
N313
L
V
R
R
E
H
A
N
I
D
A
Q
S
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001017414
412
44719
A364
L
V
R
K
E
H
A
A
I
D
A
V
A
A
P
Frog
Xenopus laevis
NP_001088636
413
45548
E370
G
W
K
A
E
L
E
E
L
V
K
K
E
H
A
Zebra Danio
Brachydanio rerio
Q7ZVK3
379
42296
E340
G
W
K
K
E
L
E
E
M
V
K
R
E
H
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650880
355
40094
K318
Q
L
I
T
S
E
R
K
K
L
S
G
S
Q
N
Honey Bee
Apis mellifera
XP_393038
355
40940
V318
H
S
N
G
A
R
D
V
A
W
L
G
E
C
D
Nematode Worm
Caenorhab. elegans
Q21921
607
68747
H531
R
D
V
H
H
E
T
H
C
E
S
S
C
G
S
Sea Urchin
Strong. purpuratus
XP_001195952
400
43895
A363
S
P
T
K
D
E
T
A
K
T
P
T
S
A
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P53686
357
39961
S320
E
N
L
S
L
D
Q
S
E
H
E
S
A
D
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82
N.A.
75.8
N.A.
87.6
78.4
N.A.
N.A.
63.3
63.4
63.5
N.A.
43.7
47.5
25.2
47.2
Protein Similarity:
100
82
N.A.
82.2
N.A.
94.5
84.5
N.A.
N.A.
78.4
76
77.8
N.A.
59.6
61.4
39.8
64.7
P-Site Identity:
100
6.6
N.A.
0
N.A.
86.6
86.6
N.A.
N.A.
60
13.3
13.3
N.A.
6.6
0
6.6
6.6
P-Site Similarity:
100
20
N.A.
6.6
N.A.
100
100
N.A.
N.A.
80
33.3
40
N.A.
20
0
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
33.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
52.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
16
8
8
31
24
8
16
31
0
16
31
24
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
8
8
0
% C
% Asp:
0
8
0
0
8
8
16
0
8
31
0
0
0
8
8
% D
% Glu:
8
8
0
8
47
24
16
16
8
8
8
0
24
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
16
0
0
8
0
0
0
0
0
0
8
16
16
31
8
% G
% His:
8
0
8
8
24
31
0
8
0
8
0
0
0
16
0
% H
% Ile:
0
0
8
0
0
8
0
8
31
0
0
0
0
0
0
% I
% Lys:
8
0
16
24
0
0
0
8
16
0
16
8
0
0
8
% K
% Leu:
31
8
8
0
8
16
0
0
8
8
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
8
8
0
0
0
0
16
0
0
0
0
0
0
8
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
8
0
0
0
16
% P
% Gln:
8
0
0
0
0
0
8
0
8
0
8
24
0
8
0
% Q
% Arg:
8
8
39
24
0
8
8
0
0
0
0
8
0
0
0
% R
% Ser:
8
8
0
8
8
0
8
16
0
0
16
31
39
0
24
% S
% Thr:
0
0
8
8
0
0
16
0
0
8
0
8
0
0
8
% T
% Val:
8
31
8
0
0
0
0
8
0
16
0
8
0
0
0
% V
% Trp:
0
16
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _